Educational Academy

  Oestrogen’s Impact on Parkinson’s Dementia: Balancing Potential Benefits and Risks Parkinson’s dementia—a cognitive decline that affects up to 80% of people with Parkinson’s disease (PD)—presents unique challenges. Emerging research suggests oestrogen may influence both motor and cognitive symptoms, but the evidence remains nuanced. Here’s what we know so far: Potential Cognitive Benefits in PD Neuroprotection for Dopamine Systems : Oestrogen appears to protect dopamine-producing neurons, which degenerate in PD. A 2019 imaging study found that postmenopausal women with longer lifetime oestrogen exposure had healthier dopamine systems and less severe motor symptoms, suggesting a possible indirect benefit for cognitive function 7 . Reduced Risk of Parkinson’s Dementia : While no studies directly target Parkinson’s dementia, a 2020 meta-analysis linked oestrogen replacement therapy (ERT) to a lower risk of d...

  Oestrogen and Parkinson’s Disease Can Oestrogen Supplements Help Women with Parkinson’s Disease? What the Science Says Parkinson’s disease (PD) affects both men and women, but women often notice changes in their symptoms after menopause, when oestrogen levels drop. This has led many to wonder: could oestrogen supplements help women with Parkinson’s manage their symptoms or even slow the disease? Here’s what the latest research tells us—summed up for the Parkinson’s community. The Link Between Oestrogen and Parkinson’s Oestrogen is a hormone best known for its role in women’s health, but it also has important effects on the brain. Scientists have noticed that women are less likely to develop Parkinson’s than men, and that risk rises after menopause. This suggests oestrogen might help protect the brain cells that are lost in Parkinson’s. A large meta-analysis pooling results from many studies found that women who used oestrogen therapy after menopause had ...